A knowledge-guided and traditional Chinese medicine informed approach for herb recommendation

Zhe JIN; Yin ZHANG; Jiaxu MIAO; Yi YANG; Yueting ZHUANG; Yunhe PAN

doi:10.1631/FITEE.2200662

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A knowledge-guided and traditional Chinese medicine informed approach for herb recommendation

Regular Papers | Updated：2023-10-25

- A knowledge-guided and traditional Chinese medicine informed approach for herb recommendation
  Enhanced Publication
- 一种知识引导的基于中医学信息的药材推荐方法
- Frontiers of Information Technology & Electronic Engineering Vol. 24, Issue 10, Pages: 1416-1429(2023)
- Affiliations：
  
  College of Computer Science and Technology, Zhejiang University, Hangzhou 310027, China
- Author bio：
  
  †E-mail: 11521043@zju.edu.cn
  ‡Corresponding author
- Funds：
- DOI：10.1631/FITEE.2200662
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Zhe JIN, Yin ZHANG, Jiaxu MIAO, et al. A knowledge-guided and traditional Chinese medicine informed approach for herb recommendation. [J]. Frontiers of Information Technology & Electronic Engineering 24(10):1416-1429(2023)
DOI：

Zhe JIN, Yin ZHANG, Jiaxu MIAO, et al. A knowledge-guided and traditional Chinese medicine informed approach for herb recommendation. [J]. Frontiers of Information Technology & Electronic Engineering 24(10):1416-1429(2023) DOI： 10.1631/FITEE.2200662.

摘要

在中国几千年历史中，中医一直是人们关注的焦点。近年来，随着人工智能技术的兴起，部分研究开始以数据驱动的方式学习中医的方剂，即根据病人的症状推荐一组药材。现有大多数药材推荐模型忽略了中医领域的知识，例如药材和症状之间的关系，中药药方形成逻辑，等等。本文提出一种以知识为引导、结合中医学信息的药材推荐方法。本文使用的知识包括从中医典籍及处方中提取的知识图谱，以此得到症状和药材之间的交互和共生关系。利用这些信息，基于图注意力网络提取症状和药材的特征向量。在此基础上，将处方学等中医学信息加入到预测层中，提高了模型对药材的预测能力。最后，在中医处方数据集上进行的实验表明，该方法优于目前主流的药材推荐算法。

Abstract

Traditional Chinese medicine (TCM) is an interesting research topic in China’s thousands of years of history. With the recent advances in artificial intelligence technology

some researchers have started to focus on learning the TCM prescriptions in a data-driven manner. This involves appropriately recommending a set of herbs based on patients’ symptoms. Most existing herb recommendation models disregard TCM domain knowledge

for example

the interactions between symptoms and herbs and the TCM-informed observations (i.e.

TCM formulation of prescriptions). In this paper

we propose a knowledge-guided and TCM-informed approach for herb recommendation. The knowledge used includes path interactions and co-occurrence relationships among symptoms and herbs from a knowledge graph generated from TCM literature and prescriptions. The aforementioned knowledge is used to obtain the discriminative feature vectors of symptoms and herbs via a graph attention network. To increase the ability of herb prediction for the given symptoms

we introduce TCM-informed observations in the prediction layer. We apply our proposed model on a TCM prescription dataset

demonstrating significant improvements over state-of-the-art herb recommendation methods.

关键词

中医药材推荐知识图谱图注意力网络

Keywords

Traditional Chinese medicineHerb recommendationKnowledge graphGraph attention network

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