

FOLLOWUS
1.MOE Key Laboratory of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China
2.Department of Signal and Information Processing, China Jiliang University, Hangzhou 310018, China
[ "Xin HAO, E-mail: sarah.xin@gmail.com" ]
Shun-ren XIA, E-mail: srxia@zju.edu.cn
Received:06 March 2012,
Revised:2012-;8-;3,
Published:2012-09
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Xin HAO, Ye SHEN, Shun-ren XIA. Automatic mass segmentation on mammograms combining random walks and active contour[J]. Frontiers of Information Technology & Electronic Engineering, 2012, 13(9): 635-648.
Xin HAO, Ye SHEN, Shun-ren XIA. Automatic mass segmentation on mammograms combining random walks and active contour[J]. Frontiers of Information Technology & Electronic Engineering, 2012, 13(9): 635-648. DOI: 10.1631/jzus.C1200052.
Accurate mass segmentation on mammograms is a critical step in computer-aided diagnosis (CAD) systems. It is also a challenging task since some of the mass lesions are embedded in normal tissues and possess poor contrast or ambiguous margins. Besides
the shapes and densities of masses in mammograms are various. In this paper
a hybrid method combining a random walks algorithm and Chan-Vese (CV) active contour is proposed for automatic mass segmentation on mammograms. The data set used in this study consists of 1095 mass regions of interest (ROIs). First
the original ROI is preprocessed to suppress noise and surrounding tissues. Based on the preprocessed ROI
a set of seed points is generated for initial random walks segmentation. Afterward
an initial contour of mass and two probability matrices are produced by the initial random walks segmentation. These two probability matrices are used to modify the energy function of the CV model for prevention of contour leaking. Lastly
the final segmentation result is derived by the modified CV model
during which the probability matrices are updated by inserting several rounds of random walks. The proposed method is tested and compared with other four methods. The segmentation results are evaluated based on four evaluation metrics. Experimental results indicate that the proposed method produces more accurate mass segmentation results than the other four methods.
Cancer Society American . . Cancer Facts & Figures 2011 . . Available from , , http://www.cancer.org/acs/groups/content/@epidemiologysurveilance/documents/document/acspc-029771.pdf http://www.cancer.org/acs/groups/content/@epidemiologysurveilance/documents/document/acspc-029771.pdf , , 2011 . . .
J.E. Ball , , , L.M. Bruce . . Digital Mammographic Computer Aided Diagnosis (CAD) Using Adaptive Level Set Segmentation . . 29th Annual Int. Conf. of the IEEE Engineering in Medicine and Biology Society , , 2007a . . p.4973 - - 4978 . . DOI: 10.1109/IEMBS.2007.4353457 http://doi.org/10.1109/IEMBS.2007.4353457 . .
J.E. Ball , , , L.M. Bruce . . Digital Mammogram Spiculated Mass Detection and Spicule Segmentation Using Level Sets . . 29th Annual Int. Conf. of the IEEE Engineering in Medicine and Biology Society , , 2007b . . p.4979 - - 4984 . . DOI: 10.1109/IEMBS.2007.4353458 http://doi.org/10.1109/IEMBS.2007.4353458 . .
Y. Cao , , , X. Hao , , , S. Xia . . An improved region-growing algorithm for mammographic mass segmentation . . SPIE , , 2009 . . 7497 74971O-1 - - 74971O-7 . . . .
Y. Cao , , , X. Hao , , , X. Zhu , , , S. Xia . . Mammographic mass segmentation algorithm based on automatic random walks . . J. Zhejiang Univ. (Eng. Sci.) , , 2011 . . 45 ( ( 10 ): ): 1753 - - 1760 . . DOI: 10.3785/j.issn.1008-973X.2011.10.009 http://doi.org/10.3785/j.issn.1008-973X.2011.10.009 . .
T.F. Chan , , , L.A. Vese . . Active contours without edges . . IEEE Trans. Image Process. , , 2001 . . 10 ( ( 2 ): ): 266 - - 277 . . DOI: 10.1109/83.902291 http://doi.org/10.1109/83.902291 . .
K.N. Chaudhury , , , K.R. Ramakrishnan . . Stability and convergence of the level set method in computer vision . . Pattern Recogn. Lett. , , 2007 . . 28 ( ( 7 ): ): 884 - - 893 . . DOI: 10.1016/j.patrec.2006.12.003 http://doi.org/10.1016/j.patrec.2006.12.003 . .
A. R. Domínguez , , , A.K. Nandi . . Improved dynamic-programming-based algorithms for segmentation of masses in mammograms . . Med. Phys. , , 2007 . . 34 ( ( 11 ): ): 4256 - - 4269 . . DOI: 10.1118/1.2791034 http://doi.org/10.1118/1.2791034 . .
L. Grady . . Random walks for image segmentation . . IEEE Trans. Pattern Anal. Mach. Intell. , , 2006 . . 28 ( ( 11 ): ): 1768 - - 1783 . . DOI: 10.1109/TPAMI.2006.233 http://doi.org/10.1109/TPAMI.2006.233 . .
D. Guliato , , , R.M. Rangayyan , , , W.A. Carnielli , , , J.A. Zuffo , , , J.E.L. Desautels . . Segmentation of Breast Tumors in Mammograms by Fuzzy Region Growing . . Proc. 20th Annual Int. Conf. of the IEEE Engineering in Medicine and Biology Society , , 1998 . . p.1002 - - 1005 . . DOI: 10.1109/IEMBS.1998.745618 http://doi.org/10.1109/IEMBS.1998.745618 . .
D. Guliato , , , R.M. Rangayyan , , , W.A. Carnielli , , , J.A. Zuffo , , , J.E.L. Desautels . . Segmentation of breast tumors in mammograms using fuzzy sets . . J. Electron. Imag. , , 2003 . . 12 ( ( 3 ): ): 369 - - 378 . . DOI: 10.1117/1.1579017 http://doi.org/10.1117/1.1579017 . .
X. Hao , , , S. Xia . . A dynamic programming algorithm for mass segmentation on mammograms based on contour supervision . . Sci. Technol. Rev. , , 2009 . . 27 ( ( 21 ): ): 56 - - 60 . . . .
M. Heath , , , K. Bowyer , , , D. Kopans , , , W.P. Kegelmeyer , , , R. Moore , , , K. Chang , , , S. MunishKumaran . . Current Status of the Digital Database for Screening Mammography . . Proc. 4th Int. Workshop on Digital Mammography , , 1998 . . p.457 - - 460 . . . .
M. Heath , , , K. Bowyer , , , D. Kopans , , , R. Moore , , , W.P. Kegelmeyer . . The Digital Database for Screening Mammography . . Proc. 5th Int. Workshop on Digital Mammography , , 2000 . . p.212 - - 218 . . . .
B.W. Hong , , , B.S. Sohn . . Segmentation of regions of interest in mammograms in a topographic approach . . IEEE Trans. Inf. Technol. Biomed. , , 2010 . . 14 ( ( 1 ): ): 129 - - 139 . . DOI: 10.1109/TITB.2009.2033269 http://doi.org/10.1109/TITB.2009.2033269 . .
M.A. Kupinski , , , M.L. Giger . . Automated seeded lesion segmentation on digital mammograms . . IEEE Trans. Med. Imag. , , 1998 . . 17 ( ( 4 ): ): 510 - - 517 . . DOI: 10.1109/42.730396 http://doi.org/10.1109/42.730396 . .
A. Oliver , , , J. Freixenet , , , J. Martí , , , E. Prez , , , J. Pont , , , E.R.E. Denton , , , R. Zwiggelaar . . A review of automatic mass detection and segmentation in mammographic images . . Med. Image Anal. , , 2010 . . 14 ( ( 2 ): ): 87 - - 110 . . DOI: 10.1016/j.media.2009.12.005 http://doi.org/10.1016/j.media.2009.12.005 . .
S. Osher , , , J.A. Sethian . . Fronts propagating with curvature-dependent speed: algorithms based on Hamilton-Jacobi formulations . . J. Comput. Phys. , , 1988 . . 79 ( ( 1 ): ): 12 - - 49 . . DOI: 10.1016/0021-9991(88)90002-2 http://doi.org/10.1016/0021-9991(88)90002-2 . .
N. Petrick , , , H.P. Chan , , , B. Sahiner , , , M.A. Helvie . . Combined adaptive enhancement and region-growing segmentation of breast masses on digitized mammograms . . Med. Phys. , , 1999 . . 26 ( ( 8 ): ): 1642 - - 1654 . . DOI: 10.1118/1.598658 http://doi.org/10.1118/1.598658 . .
W. Qian , , , L. Li , , , L.P. Clark . . Image feature extraction for mass detection in digital mammography: influence of wavelet analysis . . Med. Phys. , , 1999 . . 26 ( ( 3 ): ): 402 - - 408 . . DOI: 10.1118/1.598531 http://doi.org/10.1118/1.598531 . .
B. Sahiner , , , N. Petrick , , , H.P. Chan , , , L.M. Hadjiiski , , , C. Paramagul , , , M.A. Helvie , , , M.N. Gurcan . . Computer-aided characterization of mammographic masses: accuracy of mass segmentation and its effects on characterization . . IEEE Trans. Med. Imag. , , 2001 . . 20 ( ( 12 ): ): 1275 - - 1284 . . DOI: 10.1109/42.974922 http://doi.org/10.1109/42.974922 . .
E. Song , , , L. Jiang , , , R. Jin , , , L. Zhang , , , Y. Yuan , , , Q. Li . . Breast mass segmentation in mammography using plane fitting and dynamic programming . . Acad. Radiol. , , 2009 . . 16 ( ( 7 ): ): 826 - - 835 . . DOI: 10.1016/j.acra.2008.11.014 http://doi.org/10.1016/j.acra.2008.11.014 . .
E. Song , , , S. Xu , , , X. Xu , , , J. Zeng , , , Y. Lan , , , S. Zhang , , , C.C. Hung . . Hybrid segmentation of mass in mammograms using template matching and dynamic programming . . Acad. Radiol. , , 2010 . . 17 ( ( 11 ): ): 1414 - - 1424 . . DOI: 10.1016/j.acra.2010.07.008 http://doi.org/10.1016/j.acra.2010.07.008 . .
G.M. te Brake , , , N. Karssemeijer . . Segmentation of suspicious densities in digital mammograms . . Med. Phys. , , 2001 . . 28 ( ( 2 ): ): 259 - - 266 . . DOI: 10.1118/1.1339884 http://doi.org/10.1118/1.1339884 . .
S. Timp , , , N. Karssemeijer . . A new 2D segmentation method based on dynamic programming applied to computer aided detection in mammography . . Med. Phys. , , 2004 . . 31 ( ( 5 ): ): 958 - - 971 . . DOI: 10.1118/1.1688039 http://doi.org/10.1118/1.1688039 . .
Y. Wang , , , D. Tao , , , X. Gao , , , X. Li , , , B. Wang . . Mammographic mass segmentation: embedding multiple features in vector-valued level set in ambiguous regions . . Pattern Recogn. , , 2011 . . 44 ( ( 9 ): ): 1903 - - 1915 . . DOI: 10.1016/j.patcog.2010.08.002 http://doi.org/10.1016/j.patcog.2010.08.002 . .
M. Xiao , , , S. Xia , , , S. Wang . . Geometric Active Contour Model with Color and Intensity Priors for Medical Image Segmentation . . 27th Annual Int. Conf. of the Engineering in Medicine and Biology Society , , 2005 . . p.6496 - - 6499 . . DOI: 10.1109/IEMBS.2005.1615987 http://doi.org/10.1109/IEMBS.2005.1615987 . .
S. Xu , , , H. Liu , , , E. Song . . Marker-controlled watershed for lesion segmentation in mammograms . . J. Dig. Imag. , , 2011 . . 24 ( ( 5 ): ): 754 - - 763 . . DOI: 10.1007/s10278-011-9365-2 http://doi.org/10.1007/s10278-011-9365-2 . .
W. Xu , , , S. Xia , , , H. Duan , , , M. Xiao . . Segmentation of mass in mammograms using a novel intelligent algorithm . . Int. J. Pattern Recogn. Artif. Intell. , , 2006 . . 20 ( ( 2 ): ): 255 - - 270 . . DOI: 10.1142/S0218001406004648 http://doi.org/10.1142/S0218001406004648 . .
Y. Yuan , , , M.L. Giger , , , H. Li , , , K. Suzuki , , , C. Sennett . . A dual-stage method for lesion segmentation on digital mammograms . . Med. Phys. , , 2007 . . 34 ( ( 11 ): ): 4180 - - 4193 . . DOI: 10.1118/1.2790837 http://doi.org/10.1118/1.2790837 . .
Y. Zhang , , , N. Tomuro , , , J. Furst , , , Raicu D. Stan . . Image enhancement and edge-based mass segmentation in mammogram . . SPIE , , 2010 . . 7623 76234P-1 - - 76234P-8 . . . .
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