基于片上波导的超灵敏探测与超分辨成像

庞陈雷; 刘旭; 陈伟; 杨青

doi:10.1631/FITEE.1900211

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基于片上波导的超灵敏探测与超分辨成像

常规文章 | Updated：2022-05-19

- 基于片上波导的超灵敏探测与超分辨成像
- Chip-based waveguides for high-sensitivity biosensing and super-resolution imaging
- 信息与电子工程前沿（英文） 2020年21卷第8期页码：1134-1149
- Affiliations：
  
  State Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou 310027, China
  Deparment of Cell Biology, Zhejiang University School of Medicine, Hangzhou 310058, China
  State Key Laboratory of Modern Optical Instrumentation, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou 310058, China
  Collaborative Innovation Center of Extreme Optics, Shanxi University, Taiyuan 030006, China
- Author bio：
  
  [ "", "Chen-lei PANG, first author of this invited paper, received his PhD degree in Optical Engineering in 2019 from Zhejiang University. He was awarded a scholarship under the State Scholarship Fund to study at California Institute of Technology as a joint PhD student from March 2018 to March 2019. He currently works at Zhejiang Lab, and his research interests focus on chip-based super-resolution imaging and defect inspection" ]
  [ "", "Qing YANG, corresponding author of this invited paper, received her BS and PhD degrees in College of Materials Science and Engineering from Zhejiang University in 2001 and 2006, respectively. She was a visiting scholar at Georgia Tech from 2009 to 2012, and a visiting scientist at University of Cambridge in 2018. She is currently a professor at the State Key Laboratory of Modern Optical Instrumentation, Zhejiang University, and an associate editor of Science Bulletin. Her research interests focus on smart and high-resolution sensing and imaging based on micro/nano-photonics" ]
- Funds：
  
  Project supported by the National Natural Science Foundation of China (Nos. 61735017, 61822510, and 51672245), the Zhejiang Provincial Natural Science Foundation of China (No. R17F050003), the National Key Basic Research Program of China (No. 2015CB352003), the Fundamental Research Funds for the Central Universities, China, the Program for Zhejiang Leading Team of S & T Innovation, the Cao Guangbiao Advanced Technology Program, and the First-Class Universities and Academic Programs
- DOI：10.1631/FITEE.1900211
  中图分类号： Q248;O438.2
- 收稿：2019-04-24，
  
  修回：2020-;3-;3，
  
  纸质出版：2020-08
- Accepted：
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庞陈雷, 刘旭, 陈伟, 等. 基于片上波导的超灵敏探测与超分辨成像[J]. 信息与电子工程前沿（英文）, 2020,21(8):1134-1149.

Chen-lei PANG, Xu LIU, Wei CHEN, et al. Chip-based waveguides for high-sensitivity biosensing and super-resolution imaging[J]. Frontiers of Information Technology & Electronic Engineering, 2020, 21(8): 1134-1149.
庞陈雷, 刘旭, 陈伟, 等. 基于片上波导的超灵敏探测与超分辨成像[J]. 信息与电子工程前沿（英文）, 2020,21(8):1134-1149. DOI： 10.1631/FITEE.1900211.

Chen-lei PANG, Xu LIU, Wei CHEN, et al. Chip-based waveguides for high-sensitivity biosensing and super-resolution imaging[J]. Frontiers of Information Technology & Electronic Engineering, 2020, 21(8): 1134-1149. DOI： 10.1631/FITEE.1900211.

摘要

本综述介绍基于芯片的波导生物传感和成像技术的最新研究进展，这些技术可显著降低系统复杂度。这些技术利用波导表面的近场倏逝场与周围样品产生相互作用，实现对被检测生物分子的高灵敏探测和微纳样品的高信噪比超分辨成像。相关检测与成像波导芯片的制作过程简单，且同传统半导体加工工艺兼容，具有大规模生产应用前景。通过与近年来快速发展的片上集成光源结合，这些技术为实现片上系统集成的生物分子检测和超分辨成像提供了可能。

Abstract

In this review

we introduce some chip-based waveguide biosensing and imaging techniques

which significantly reduce the complexity of the entire system. These techniques use a well-confined evanescent field to interact with the surrounding materials and achieve high sensitivity sensing and high signal-to-noise ratio (SNR) super-resolution imaging. The fabrication process of these chips is simple and compatible with conventional semiconductor fabrication methods

allowing high-yield production. Combined with recently developed chip-based light sources

these techniques offer the possibility of biosensing and super-resolution imaging based on integrated circuits.

关键词

Keywords

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