基于双向脑机接口的癫痫抑制系统

Yu QI; Fei-qiang MA; Ting-ting GE; Yue-ming WANG; Jun-ming ZHU; Jian-min ZHANG; Xiao-xiang ZHENG; Zhao-hui WU

doi:10.1631/jzus.C1400152

Your Location：

Home >

Browse articles >

基于双向脑机接口的癫痫抑制系统

脑机接口与半机器人智能专题 | Updated：2022-05-19

- 基于双向脑机接口的癫痫抑制系统
- A bidirectional brain-computer interface for effective epilepsy control
- 信息与电子工程前沿（英文） 2014年15卷第10期页码：839-847
- Affiliations：
  
  1.Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou 310027, China
  2.Department of Computer Science, Zhejiang University, Hangzhou 310027, China
  3.Second Affiliated Hospital of Zhejiang University College of Medicine, Hangzhou 310027, China
  4.College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou 310027, China
- Author bio：
  
  Yue-ming WANG, E-mail: ymingwang@zju.edu.cn
- Funds：
  
  Project supported by the National Basic Research Program (973) of China (No. 2013CB329500), the National High-Tech R&D Program (863) of China (No. 2012AA020408), the National Natural Science Foundation of China (No. 61103107), and the Research Fund for the Doctoral Program of Higher Education of China (No. 20110101120154)
- DOI：10.1631/jzus.C1400152
  中图分类号： TP39;R31
- 收稿：2014-04-26，
  
  修回：2014-;9-17，
  
  纸质出版：2014-10
- Accepted：
Scan QR Code
基于双向脑机接口的癫痫抑制系统[J]. 信息与电子工程前沿（英文）, 2014,15(10):839-847.

Yu QI, Fei-qiang MA, Ting-ting GE, et al. A bidirectional brain-computer interface for effective epilepsy control[J]. Frontiers of Information Technology & Electronic Engineering, 2014, 15(10): 839-847.
基于双向脑机接口的癫痫抑制系统[J]. 信息与电子工程前沿（英文）, 2014,15(10):839-847. DOI： 10.1631/jzus.C1400152.

Yu QI, Fei-qiang MA, Ting-ting GE, et al. A bidirectional brain-computer interface for effective epilepsy control[J]. Frontiers of Information Technology & Electronic Engineering, 2014, 15(10): 839-847. DOI： 10.1631/jzus.C1400152.

摘要

研究目的

皮层电刺激作为新的治疗手段

能够有效抑制癫痫发作，弥补传统癫痫治疗方法的不足。现有电刺激治疗方法大都采用持续刺激的方式，或遵照既定的刺激方案，刺激量大，副作用强，尚未广泛应用于临床。脑机接口技术有望为电刺激治疗提供有效闭环控制，从而降低电刺激带来的组织损伤和副作用。

创新要点

首先，提出"双阈值"癫痫检测算法，针对癫痫脑电波形态特征，实现在线快速检测；其次，建立闭环脑机接口系统，通过反应性高频皮层刺激，有效抑制癫痫。

试验结果

通过建立双向脑机接口技术，对脑电信号进行实时分析，从而在癫痫发作前期将其准确检测出来，并触发反应性电刺激，有效抑制癫痫。在青霉素癫痫大鼠模型上的对照试验表明，基于癫痫脑电形态学特征的癫痫检测方法，癫痫检测率83%，平均检测延迟3.11秒；实验组相比于对照组，平均癫痫发作时间减少30.7%。

重要结论

通过双向闭环脑机接口系统，能够实现"按需刺激"，从而大大降低电刺激量，减小副作用和组织损伤。基于脑机接口的反应性电刺激系统，能够对癫痫进行实时检测和刺激，有效抑制癫痫发作。该系统具有临床应用潜力。

Abstract

Brain-computer interfaces (BCIs) can provide direct bidirectional communication between the brain and a machine. Recently

the BCI technique has been used in seizure control. Usually

a closed-loop system based on BCI is set up which delivers a therapic electrical stimulus only in response to seizure onsets. In this way

the side effects of neurostimulation can be greatly reduced. In this paper

a new BCI-based responsive stimulation system is proposed. With an efficient morphology-based seizure detector

seizure events can be identified in the early stages which trigger electrical stimulations to be sent to the cortex of the brain. The proposed system was tested on rats with penicillin-induced epileptic seizures. Online experiments show that 83% of the seizures could be detected successfully with a short average time delay of 3.11 s. With the therapy of the BCI-based seizure control system

most seizures were suppressed within 10 s. Compared with the control group

the average seizure duration was reduced by 30.7%. Therefore

the proposed system can control epileptic seizures effectively and has potential in clinical applications.

关键词

Keywords

references

A. Berényi , , , M. Belluscio , , , D. Mao , , , 等 . . Closedloop control of epilepsy by transcranial electrical stimulation . . Science , , 2012 . . 337 ( ( 6095 ): ): 735 - - 737 . . DOI: 10.1126/science.1223154 http://doi.org/10.1126/science.1223154 . .

M. Bikson , , , J. Lian , , , P.J. Hahn , , , 等 . . Suppression of epileptiform activity by high frequency sinusoidal fields in rat hippocampal slices . . J. Physiol , , 2001 . . 531 ( ( 1 ): ): 181 - - 191 . . DOI: 10.1111/j.1469-7793.2001.0181j.x http://doi.org/10.1111/j.1469-7793.2001.0181j.x . .

P.R. Carney , , , S. Myers , , , J.D. Geyer . . Seizure prediction: methods . . Epilepsy Behav , , 2011 . . 22 ( ( Suppl 1 ): ): S94 - - S101 . . DOI: 10.1016/j.yebeh.2011.09.001 http://doi.org/10.1016/j.yebeh.2011.09.001 . .

J.Jr. Engel , , , S. Wiebe , , , J. French , , , 等 . . Practice parameter: temporal lobe and localized neocortical resections for epilepsy . . Epilepsia , , 2003 . . 44 ( ( 6 ): ): 741 - - 751 . . DOI: 10.1046/j.1528-1157.2003.48202.x http://doi.org/10.1046/j.1528-1157.2003.48202.x . .

R. Fisher , , , V. Salanova , , , T. Witt , , , 等 . . Electrical stimulation of the anterior nucleus of thalamus for treatment of refractory epilepsy . . Epilepsia , , 2010 . . 51 ( ( 5 ): ): 899 - - 908 . . DOI: 10.1111/j.1528-1167.2010.02536.x http://doi.org/10.1111/j.1528-1167.2010.02536.x . .

S. Grewal , , , J. Gotman . . An automatic warning system for epileptic seizures recorded on intracerebral EEGs . . Clin. Neurophysiol , , 2005 . . 116 ( ( 10 ): ): 2460 - - 2472 . . DOI: 10.1016/j.clinph.2005.05.020 http://doi.org/10.1016/j.clinph.2005.05.020 . .

L.R. Hochberg , , , D. Bacher , , , B. Jarosiewicz , , , 等 . . Reach and grasp by people with tetraplegia using a neurally controlled robotic arm . . Nature , , 2012 . . 485 ( ( 7398 ): ): 372 - - 375 . . DOI: 10.1038/nature11076 http://doi.org/10.1038/nature11076 . .

M. Kinoshita , , , A. Ikeda , , , M. Matsuhashi , , , 等 . . Electric cortical stimulation suppresses epileptic and background activities in neocortical epilepsy and mesial temporal lobe epilepsy . . Clin. Neurophysiol , , 2005 . . 116 ( ( 6 ): ): 1291 - - 1299 . . DOI: 10.1016/j.clinph.2005.02.010 http://doi.org/10.1016/j.clinph.2005.02.010 . .

E.H. Kossoff , , , E.K. Ritzl , , , J.M. Politsky , , , 等 . . Effect of an external responsive neurostimulator on seizures and electrographic discharges during subdural electrode monitoring . . Epilepsia , , 2004 . . 45 ( ( 12 ): ): 1560 - - 1567 . . DOI: 10.1111/j.0013-9580.2004.26104.x http://doi.org/10.1111/j.0013-9580.2004.26104.x . .

P. Kwan , , , M.J. Brodie . . Early identification of refractory epilepsy . . N. Engl. J. Med , , 2000 . . 342 ( ( 5 ): ): 314 - - 319 . . DOI: 10.1056/NEJM200002033420503 http://doi.org/10.1056/NEJM200002033420503 . .

K.K. Majumdar , , , P. Vardhan . . Automatic seizure detection in ECoG by differential operator and windowed variance . . IEEE Trans. Neur. Syst. Rehabil. Eng , , 2011 . . 19 ( ( 4 ): ): 356 - - 365 . . DOI: 10.1109/TNSRE.2011.2157525 http://doi.org/10.1109/TNSRE.2011.2157525 . .

F. Mormann , , , R.G. Andrzejak , , , C.E. Elger , , , 等 . . Seizure prediction: the long and winding road . . Brain , , 2007 . . 130 ( ( 2 ): ): 314 - - 333 . . DOI: 10.1093/brain/awl241 http://doi.org/10.1093/brain/awl241 . .

M. Morrell . . Responsive cortical stimulation for the treatment of medically intractable partial epilepsy . . Neurology , , 2011 . . 77 ( ( 13 ): ): 1295 - - 1304 . . DOI: 10.1212/WNL.0b013e3182302056 http://doi.org/10.1212/WNL.0b013e3182302056 . .

G.K. Motamedi , , , R.P. Lesser , , , D.L. Miglioretti , , , 等 . . Optimizing parameters for terminating cortical afterdischarges with pulse stimulation . . Epilepsia , , 2002 . . 43 ( ( 8 ): ): 836 - - 846 . . DOI: 10.1046/j.1528-1157.2002.24901.x http://doi.org/10.1046/j.1528-1157.2002.24901.x . .

I. Osorio , , , M.G. Frei , , , S. Sunderam , , , 等 . . Automated seizure abatement in humans using electrical stimulation . . Ann. Neurol , , 2005 . . 57 ( ( 2 ): ): 258 - - 268 . . DOI: 10.1002/ana.20377 http://doi.org/10.1002/ana.20377 . .

G. Pfurtscheller , , , D. Flotzinger , , , J. Kalcher . . Braincomputer interface-a new communication device for handicapped persons . . J. Microcomput. Appl , , 1993 . . 16 ( ( 3 ): ): 293 - - 299 . . DOI: 10.1006/jmca.1993.1030 http://doi.org/10.1006/jmca.1993.1030 . .

D.M. Psatta . . Control of chronic experimental focal epilepsy by feedback caudatum stimulations . . Epilepsia , , 1983 . . 24 ( ( 4 ): ): 444 - - 454 . . DOI: 10.1111/j.1528-1157.1983.tb04915.x http://doi.org/10.1111/j.1528-1157.1983.tb04915.x . .

B. Rosin , , , M. Slovik , , , R. Mitelman , , , 等 . . Closedloop deep brain stimulation is superior in ameliorating parkinsonism . . Neuron , , 2011 . . 72 ( ( 2 ): ): 370 - - 384 . . DOI: 10.1016/j.neuron.2011.08.023 http://doi.org/10.1016/j.neuron.2011.08.023 . .

F.T. Sun , , , M.J. Morrell , , , R.E.Jr. Wharen . . Responsive cortical stimulation for the treatment of epilepsy . . Neurotherapeutics , , 2007 . . 5 ( ( 1 ): ): 68 - - 74 . . DOI: 10.1016/j.nurt.2007.10.069 http://doi.org/10.1016/j.nurt.2007.10.069 . .

A.L. Velasco , , , F. Velasco , , , M. Velasco , , , 等 . . Electrical stimulation of the hippocampal epileptic foci for seizure control: a double-blind, long-term follow-up study . . Epilepsia , , 2007 . . 48 ( ( 10 ): ): 1895 - - 1903 . . DOI: 10.1111/j.1528-1167.2007.01181.x http://doi.org/10.1111/j.1528-1167.2007.01181.x . .

F. Velasco , , , M. Velasco , , , F. Jimenez , , , 等 . . Stimulation of the central median thalamic nucleus for epilepsy . . Stereotact. Funct. Neurosurg , , 2001 . . 77 ( ( 1-4 ): ): 228 - - 232 . . DOI: 10.1159/000064611 http://doi.org/10.1159/000064611 . .

F. Velasco , , , J.D. Carrillo-Ruiz , , , F. Brito , , , 等 . . Double-blind, randomized controlled pilot study of bilateral cerebellar stimulation for treatment of intractable motor seizures . . Epilepsia , , 2005 . . 46 ( ( 7 ): ): 1071 - - 1081 . . DOI: 10.1111/j.1528-1167.2005.70504.x http://doi.org/10.1111/j.1528-1167.2005.70504.x . .

M. Velliste , , , S. Perel , , , M.C. Spalding , , , 等 . . Cortical control of a prosthetic arm for self-feeding . . Nature , , 2008 . . 453 ( ( 7198 ): ): 1098 - - 1101 . . DOI: 10.1038/nature06996 http://doi.org/10.1038/nature06996 . .

K. Vonck , , , P. Boon , , , E. Achten , , , 等 . . Long-term amygdalohippocampal stimulation for refractory temporal lobe epilepsy . . Ann. Neurol , , 2002 . . 52 ( ( 5 ): ): 556 - - 565 . . DOI: 10.1002/ana.10323 http://doi.org/10.1002/ana.10323 . .

L. Wang , , , H. Guo , , , X. Yu , , , 等 . . Responsive electrical stimulation suppresses epileptic seizures in rats . . PLoS ONE , , 2012 . . 7 ( ( 5 ): ): e38141 DOI: 10.1371/journal.pone.0038141 http://doi.org/10.1371/journal.pone.0038141 . .

S. Wang , , , D.C. Wu , , , M.P. Ding , , , 等 . . Lowfrequency stimulation of cerebellar fastigial nucleus inhibits amygdaloid kindling acquisition in Sprague-Dawley rats . . Neurobiol. Dis , , 2008 . . 29 ( ( 1 ): ): 52 - - 58 . . DOI: 10.1016/j.nbd.2007.07.027 http://doi.org/10.1016/j.nbd.2007.07.027 . .

J.R. Wolpaw , , , N. Birbaumer , , , W.J. Heetderks , , , 等 . . Brain-computer interface technology: a review of the first international meeting . . IEEE Trans. Rehabil. Eng , , 2000 . . 8 ( ( 2 ): ): 164 - - 173 . . DOI: 10.1109/TRE.2000.847807 http://doi.org/10.1109/TRE.2000.847807 . .

J.R. Wolpaw , , , N. Birbaumer , , , D.J. McFarland , , , 等 . . Brain-computer interfaces for communication and control . . Clin. Neurophysiol , , 2002 . . 113 ( ( 6 ): ): 767 - - 791 . . DOI: 10.1016/S1388-2457(02)00057-3 http://doi.org/10.1016/S1388-2457(02)00057-3 . .

Z. Wu , , , R. Reddy , , , G. Pan , , , 等 . . The convergence of machine and biological intelligence . . IEEE Intell. Syst , , 2013 . . 28 ( ( 5 ): ): 28 - - 43 . . DOI: 10.1109/MIS.2013.137 http://doi.org/10.1109/MIS.2013.137 . .

R. Yadav , , , M.N.S. Swamy , , , R. Agarwal . . Modelbased seizure detection for intracranial EEG recordings . . IEEE Trans. Biomed. Eng , , 2012 . . 59 ( ( 5 ): ): 1419 - - 1428 . . DOI: 10.1109/TBME.2012.2188399 http://doi.org/10.1109/TBME.2012.2188399 . .

浏览量

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

Examination of the wavelet-based approach for measuring self-similarity of epileptic electroencephalogram data

Coordinated control of an intelligent wheelchair based on a brain-computer interface and speech recognition