靶向肌肉神经功能重建机理研究

Hui ZHOU; Lin YANG; Feng-xia WU; Jian-ping HUANG; Liang-qing ZHANG; Ying-jian YANG; Guang-lin LI

doi:10.1631/jzus.C1400154

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靶向肌肉神经功能重建机理研究

脑机接口与半机器人智能专题 | Updated：2022-05-19

- 靶向肌肉神经功能重建机理研究
- Exploring the mechanism of neural-function reconstruction by reinnervated nerves in targeted muscles
- 信息与电子工程前沿（英文） 2014年15卷第10期页码：813-820
- Affiliations：
  
  1.Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China
  2.Department of Rehabilitation Medicine, Nanshan Hospital Affiliated to Guangdong Medical College, Shenzhen 518052, China
  3.Sino-Dutch Biomedical and Information Engineering School of Northeastern University, Shenyang 110004, China
- Author bio：
  
  Guang-lin LI, E-mail: gl.li@siat.ac.cn
- Funds：
  
  Project supported by the National Basic Research Program (973) of China (No. 2013CB329505), the National Natural Science Foundation of China (Nos. 61135004 and 61201114), the China Postdoctoral Science Foundation (No. 2013M541046), the Shenzhen Governmental Basic Research Grant (No. JCYJ20120617115010496), and the State Key Laboratory of Bioelectronics of Southeast University
- DOI：10.1631/jzus.C1400154
  中图分类号： TP212.3;Q189
- 收稿：2014-04-26，
  
  修回：2014-;9-17，
  
  纸质出版：2014-10
- Accepted：
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靶向肌肉神经功能重建机理研究[J]. 信息与电子工程前沿（英文）, 2014,15(10):813-820.

Hui ZHOU, Lin YANG, Feng-xia WU, et al. Exploring the mechanism of neural-function reconstruction by reinnervated nerves in targeted muscles[J]. Frontiers of Information Technology & Electronic Engineering, 2014, 15(10): 813-820.
靶向肌肉神经功能重建机理研究[J]. 信息与电子工程前沿（英文）, 2014,15(10):813-820. DOI： 10.1631/jzus.C1400154.

Hui ZHOU, Lin YANG, Feng-xia WU, et al. Exploring the mechanism of neural-function reconstruction by reinnervated nerves in targeted muscles[J]. Frontiers of Information Technology & Electronic Engineering, 2014, 15(10): 813-820. DOI： 10.1631/jzus.C1400154.

摘要

研究目的

靶向肌肉神经重建（target muscle reinnervation

TMR）技术通过对靶向肌肉植入新的神经，实现神经对靶向肌肉的重新支配。TMR技术可以为截肢患者提供丰富的肌电信息源，并可实现对假肢的直觉控制。临床上TMR已取得成功，但神经重建后功能康复过程和机理的研究仍然缺乏。本文通过建立基于大鼠的靶向肌肉神经重建模型，研究神经重建后神经肌肉功能的重建过程与潜在机理。

创新要点

将大鼠正中神经横断后移植到胸大肌上，建立基于大鼠的靶向肌肉神经重建模型，研究靶向肌肉神经重建的功能康复情况及内在神经机理；首次通过可植入电极实时获取大鼠肌肉内肌电信息，并评价神经重建后神经肌肉功能恢复情况；应用基于小波滤波器阵列的包络线提取方法，抽取肌肉活动时的肌电信息用于评价肌肉功能。

重要结论

动物实验结果表明：神经重建的大鼠靶向肌肉，在神经重建后一周内出现肌电信号，并随时间逐渐增强；失神经支配的靶向肌肉，其肌电信号并无改善。通过对神经重建后功能恢复及机理的研究，人们可探索不同治疗方法对神经重建的作用，改善神经重建效果，优化肌电假肢控制。

Abstract

A lack of myoelectric sources after limb amputation is a critical challenge in the control of multifunctional motorized prostheses. To reconstruct myoelectric sources physiologically related to lost limbs

a newly proposed neural-function construction method

targeted muscle reinnervation (TMR)

appears promising. Recent advances in the TMR technique suggest that TMR could provide additional motor command information for the control of multifunctional myoelectric prostheses. However

little is known about the nature of the physiological functional recovery of the reinnervated muscles. More understanding of the underlying mechanism of TMR could help us fine tune the technique to maximize its capability to achieve a much higher performance in the control of multifunctional prostheses. In this study

rats were used as an animal model for TMR surgery involving transferring a median nerve into the pectoralis major

which served as the target muscle. Intramuscular myoelectric signals reconstructed following TMR were recorded by implanted wire electrodes and analyzed to explore the nature of the neural-function reconstruction achieved by reinnervation of targeted muscles. Our results showed that the active myoelectric signal reconstructed in the targeted muscle was acquired one week after TMR surgery

and its amplitude gradually became stronger over time. These preliminary results from rats may serve as a basis for exploring the mechanism of neural-function reconstruction by the TMR technique in human subjects.

关键词

Keywords

references

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